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Hum. Reprod. Advance Access originally published online on June 12, 2008
Human Reproduction 2008 23(9):2010-2016; doi:10.1093/humrep/den210
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© The Author 2008. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org
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A 38 h interval between hCG priming and oocyte retrieval increases in vivo and in vitro oocyte maturation rate in programmed IVM cycles{dagger}

Weon-Young Son1, Jin-Tae Chung, Ri-Cheng Chian, Belen Herrero, Ezgi Demirtas, Shai Elizur, Yariv Gidoni, Camille Sylvestre, Nicola Dean and Seang Lin Tan

McGill Reproductive Center, Department of Obstetrics and Gynecology, Royal Victoria Hospital, McGill University, Montreal, QC, Canada H3A 1A1

1 Correspondence address. Fax: +1-514-843-1496; E-mail: weon-young.son{at}muhc.mcgill.ca

BACKGROUND: Our aim was to evaluate whether extending the interval between human chorionic gonadotrophin (hCG) priming and immature oocyte retrieval increases the oocyte maturation rate following in vitro maturation (IVM).

METHODS: This study was performed retrospectively. IVM was performed on 113 polycystic ovary syndrome patients (n = 120 cycles). Oocyte collection was performed either 35 h (Group 1; n = 76) or 38 h (Group 2; n = 44) after 10 000 IU of hCG priming. Following oocyte retrieval, oocyte maturity was assessed and the remaining immature oocytes were cultured in IVM medium up to Day 2.

RESULTS: The number of in vivo matured oocytes collected was significantly higher in Group 2 (13.6%, 114/840 versus 7.3%, 96/1312 in Group 1) (P < 0.01); the oocyte maturation rate after Day 1 was significantly higher (P < 0.01) in Group 2 (46.3 versus 36.0% in Group 1); and clinical pregnancy (40.9 versus 25%) and implantation rates (15.6 versus 9.6%) were better in Group 2 than those in Group 1.

CONCLUSIONS: The results suggest that extending the period of hCG priming time from 35 to 38 h for immature oocyte retrieval promotes oocyte maturation in vivo and increases the IVM rate of immature oocytes. Therefore, oocyte retrieval after 38 h of hCG priming may improve subsequent pregnancy outcome in cycles programmed for IVM treatment.

Key words: hCG priming/in vitro maturation (IVM)/oocyte collection time/polycystic ovarian syndrome (PCOS)/pregnancy

{dagger} Presented at the Annual Meeting of the American Society for Reproductive Medicine, Washington, DC, USA, October 13–17, 2007

Submitted on December 20, 2007; resubmitted on April 23, 2008; accepted on May 7, 2008.


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