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Hum. Reprod. Advance Access originally published online on June 25, 2008
Human Reproduction 2008 23(9):2056-2063; doi:10.1093/humrep/den154
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© The Author 2008. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org
The online version of this article has been published under an open access model. Users are entitled to use, reproduce, disseminate, or display the open access version of this article for non-commercial purposes provided that: the original authorship is properly and fully attributed: the Journal and Oxford University Press are attributed as the original place of publication with the correct citation details given: if an article is subsequently reproduced or disseminated not in its entirety but only in part or as a derivative word this must be clearly indicated. For commercial re-use, please contact journals.permissions@oxfordjournals.org

Prevalence of psychiatric disorders in infertile women and men undergoing in vitro fertilization treatment

H. Volgsten1,3, A. Skoog Svanberg1, L. Ekselius2, Ö. Lundkvist1 and I. Sundström Poromaa1

1 Department of Women's and Children's Health, Uppsala University Hospital, 751 85 Uppsala, Sweden 2 Department of Neuroscience, Psychiatry, Uppsala University, Uppsala, Sweden

3 Correspondence address. Tel: +46-18-611-57-87; Fax: +46-18-55-97-75; E-mail: helena.volgsten{at}kbh.uu.se

BACKGROUND: This study was undertaken to determine the prevalence of psychiatric disorders in infertile women and men undergoing in vitro fertilization (IVF) treatment.

METHODS: Participants were 1090 consecutive women and men, 545 couples, attending a fertility clinic in Sweden during a two-year period. The Primary Care Evaluation of Mental Disorders (PRIME-MD), based on the Diagnostic and Statistical Manual of Mental Disorders, 4th edn (DSM-IV), was used as the diagnostic tool for evaluating mood and anxiety disorders.

RESULTS: Overall, 862 (79.1%) subjects filled in the PRIME-MD patient questionnaire. Any psychiatric diagnosis was present in 30.8% of females and in 10.2% of males in the study sample. Any mood disorder was present in 26.2% of females and 9.2% of males. Major depression was the most common mood disorder, prevalent in 10.9% of females and 5.1% of males. Any anxiety disorder was encountered in 14.8% of females and 4.9% males. Only 21% of the subjects with a psychiatric disorder according to DSM-IV received some form of treatment.

CONCLUSIONS: Mood disorders are common in both women and men undergoing IVF treatment. The majority of subjects with a psychiatric disorder were undiagnosed and untreated.

Key words: depression/anxiety/women/men/in vitro fertilization

Submitted on November 13, 2007; resubmitted on March 20, 2008; accepted on April 8, 2008.


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